آنتی بادی مونوکلونال فلوسایتومتری( CD7-APC(HULY-M2 ، کلون HULY-M2

Name: Flow Cytometry Antibody CD7-APC (HULY-M2), Clone HULY-M2

• Antibody CD7-APC is a monoclonal antibody (mAb) labelled with the Allophycocyanine (APC) designed for use as a direct immunofluorescence reagent in the identification and enumeration of cells which express the CD7 antigen by flow cytometry (FC). The CD7 mAb is considered essential for the initial evaluation of T-cell acute lymphoblastic leukaemias (T-ALL) and T-cell chronic leukaemias together with a panel of other antibodies. This reagent must be used by flow cytometry qualified personal.

SUMMARY AND EXPLANATION

CD7 is a 40KDa glycoprotein expressed on thymocytes, mature T cells, natural killer cells, pluripotent hematopoietic stem cells, and progenitors of lymphoid and myeloid cells. CD7 is one of the earliest T-cell-specific antigens to be expressed in lymphocytes, and the only early marker to persist throughout differentiation. Analysis of the expression of the CD7 antigen as a T cell line marker, in combination with those CD3 and CD5 antigens, is useful in the diagnosis of T cell proliferative syndromes such as T-ALL and T-prolymphocyte T cell leukaemias. The absence of expression of CD7, or its abnormal expression, can provide useful information in the case of Sezary’s syndrome or chronic lymphoid leukaemia. The CD7 antigen can be expressed by certain acute immature myeloid leukaemias.

REAGENT COMPOSITION

Purified monoclonal CD7 Antibody Allophycocyanine (APC) conjugated, is supplied in phosphate-buffered saline (PBS) containing 1% (m/v) BSA and 0.09% (m/v) sodium azide.

• Clone: HULY-M2
• Isotype: Mouse / IgG2a
• Purification: Affinity chromatography
• Amount per 1 ml vial: 200 tests (5 ml mAb to 106 cells)
• Reagents are not considered sterile.